Philip L. De Jager, MD, PhD
The Columbia University ADRC’s Neuroimmunology Core supports the development of biosample and data resources along one of the three thematic axes of the ADRC. Characterizing immune responses is an important component of AD investigations, but these responses are not solely responsible for the disease. Thus, it is important to integrate thoughtful, informed study design, specialized resources as well as emerging experimental and analytic pipelines for systematic immune function characterization with existing biomarker, genetic, neuroimaging, and other resources to assemble a comprehensive approach to AD investigations. Our understanding of the role of the immune system in AD is rapidly evolving, and innate immune cells appear to play a key role.