Clinical Trials

  • Principal Investigator:

    Jennifer M. Bain, MD, PhD
    A natural history study of hnRNP and other genetic neurodevelopmental disorders.
  • Principal Investigator:

    Andrew B. Lassman, MD
    The purpose of this research study is to see if the combination of medications approved for the treatment of glioblastoma, together with the study drug, selinexor (also known as XPOVIO), has any effects on your cancer. Selinexor works by trapping tumor suppressor proteins within the cell nucleus. This is expected to cause the cancer cells to die or stop growing. Selinexor is approved by the U.S. Food and Drug Administration (FDA) for the use in certain patients with multiple myeloma but has not yet been approved by the FDA for the treatment of your type of cancer.
  • Principal Investigator:

    Andrew B. Lassman, MD
    The purpose of this research study is to see if the combination of medications approved for the treatment of glioblastoma, together with the study drug, selinexor (also known as XPOVIO), has any effects on your cancer. Selinexor works by trapping tumor suppressor proteins within the cell nucleus. This is expected to cause the cancer cells to die or stop growing. Selinexor is approved by the U.S. Food and Drug Administration (FDA) for the use in certain patients with multiple myeloma but has not yet been approved by the FDA for the treatment of your type of cancer.
  • Principal Investigator:

    Richard P. Mayeux, MD, MSc
    The goal of this study is to focus on the genetic influences on Alzheimer's disease (AD) risk. Weare looking for families and/or individuals (affected or unaffected) of any ethnic background with a family history of Alzheimer's disease and willing to participate.
  • Principal Investigator:

    Victoria M. Leavitt, PHD
    ASPIRE is a clinical trial to investigate aspirin as a treatment to improve exercise performance in people with multiple sclerosis (MS) who experience overheating during exercise. Persons with multiple sclerosis benefit from exercise, but many avoid it because of exhaustion and overheating. This randomized controlled trial (RCT) tests aspirin as a method to increase time to exhaustion for persons with MS, through its antipyretic mechanism. Participants will be seen at our laboratory for maximal exercise tests on three separate days. At each session, they will be given one of three treatments...
  • Principal Investigator:

    Adam M. Brickman, PhD
    The purpose of this study is to better understand how vascular health affects your thinking abilities. We hope that these findings will ultimately lead to treatments aimed to reduce cognitive impairment and dementia. We are actively recruiting adults between the ages of 65 and 90 who note a decline in memory orthinking over the past 3 years and who are of African American, Hispanic/Latino, or European ancestry. You will be asked to return to the Columbia University Medical Center every 12 to 18 months for a total of 3 assessments. At each visit, you will be asked to complete a series of...
  • Principal Investigator:

    Fabio M. Iwamoto, MD
    The purpose of this study is to test whether using clindamycin and triamcinolone topical lotions can prevent skin-related side effects of tumor treating fields (TTFields). Clindamycin is an antibiotic. It works by slowing or stopping the growth of bacteria. The FDA has approved the drug for the treatment of various bacterial infections. However, giving clindamycin to people to prevent skin-related side effects of TTFields is an investigational use of the drug. The FDA has not approved this use. Triamcinolone is a corticosteroid. It works by copying the effects of hormones that your body makes...
  • Principal Investigator:

    Fabio M. Iwamoto, MD
    The purpose of this study is to test whether using clindamycin and triamcinolone topical lotions canprevent skin-related side effects of tumor treating fields (TTFields). Clindamycin is an antibiotic. It works by slowing or stopping the growth of bacteria. The FDA has approved the drug for the treatment of various bacterial infections. However, giving clindamycin to people to prevent skin-related side effects of TTFields is an investigational use of the drug. The FDA has not approved this use. Triamcinolone is a corticosteroid. It works by copying the effects of hormones that your body makes...
  • Principal Investigator:

    Mary R. Welch, MD
    This research study will collect tissues and medical information on research subjects with neurological disorders and provide the tissues and information to researchers so they may learn more about neurological disorders and how best to prevent, detect, and treat them.
  • Principal Investigator:

    Rebecca Straus Farber, MD
    We need your help today to gather information about the experience of patients with autoimmune diseases of the central nervous system (multiple sclerosis (MS), neuromyelitis optica (NMO), and antiMOG associated disease (MOGAD)) in regards to COVID19 vaccines. Because individuals with MS, NMO, and MOGAD were not included in the COVID19 vaccine trials, we want to learn more about the experience of individuals with these autoimmune diseases and the vaccine. Because many patients with central nervous system autoimmune disease also take medications that affect the immune system, we want to find...

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