Publications

APOE- ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer's disease. Prabesh Bhattarai, Elanur Yilmaz, Elif Öykü Cakir, Hande Yüceer Korkmaz, Annie J Lee, Yiyi Ma, Hilal Celikkaya, Mehmet Ilyas Cosacak, Verena Haage, Xue Wang, Nastasia Nelson, Weilin Lin, Yixin Zhang, Tal Nuriel, Dörthe Jülich, Özkan Iş, Scott A Holley, Philip de Jager, Elizabeth Fisher, Kate Tubbesing, Andrew F Teich, Taylor Bertucci, Sally Temple, Nilüfer Ertekin-Taner, Badri N Vardarajan, Richard Mayeux, Caghan Kizil. bioRxiv [Preprint]. 2025 Jan 27:2025.01.24.634732. doi: 10.1101/2025.01.24.634732.

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late-Onset Alzheimer's Disease. Lee H, Pearse RV 2nd, Lish AM, Pan C, Augur ZM, Terzioglu G, Gaur P, Liao M, Fujita M, Tio ES, Duong DM, Felsky D, Seyfried NT, Menon V, Bennett DA, De Jager PL, Young-Pearse TL.Glia. 2025 Feb 3. doi: 10.1002/glia.24677. Online ahead of print.PMID: 39901616

Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium. Elyaman W, Stern LJ, Jiang N, Dressman D, Bradley P, Klatzmann D, Bradshaw EM, Farber DL, Kent SC, Chizari S, Funk K, Devanand D, Thakur KT, Raj T, Dalahmah OA, Sarkis RA, Weiner HL, Shneider NA, Przedborski S. Alzheimers Dement. 2025 Jan 27:e14548. doi: 10.1002/alz.14548. Online ahead of print.PMID: 39868844

Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference. Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang YA, Jackvony S, Lai L, Guen YL, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MG, Wilcock DM. Alzheimers Dement. 2025 Jan;21(1):e14291. doi: 10.1002/alz.14291. Epub 2024 Dec 18.PMID: 39692624 Free PMC article. Review.

Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction. Özkan İş, Xue Wang, Joseph S Reddy, Yuhao Min, Elanur Yilmaz, Prabesh Bhattarai, Tulsi Patel, Jeremiah Bergman, Zachary Quicksall, Michael G Heckman, Frederick Q Tutor-New, Birsen Can Demirdogen, Launia White, Shunsuke Koga, Vincent Krause, Yasuteru Inoue, Takahisa Kanekiyo, Mehmet Ilyas Cosacak, Nastasia Nelson, Annie J Lee, Badri Vardarajan, Richard Mayeux, Naomi Kouri, Kaancan Deniz , Troy Carnwath, Stephanie R Oatman, Laura J Lewis-Tuffin, Thuy Nguyen; Alzheimer’s Disease Neuroimaging Initiative; Minerva M Carrasquillo, Jonathan Graff-Radford, Ronald C Petersen, Clifford R Jr Jack, Kejal Kantarci, Melissa E Murray, Kwangsik Nho, Andrew J Saykin, Dennis W Dickson, Caghan Kizil, Mariet Allen, Nilüfer Ertekin-Taner. Nat Commun. 2024 Jun 20;15(1):4758. doi: 10.1038/s41467-024-48926-6.

Association of ten VEGF family genes with Alzheimer's disease endophenotypes at single cell resolution. Wu Y, Libby JB, Dumitrescu LC, De Jager PL, Menon V, Schneider JA, Bennett DA, Hohman TJ.Alzheimers Dement. 2024 Dec 6. doi: 10.1002/alz.14419. Online ahead of print.PMID: 39641382.

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H. Neuron. 2024 Dec 4;112(23):3984-3985. doi: 10.1016/j.neuron.2024.11.001. Epub 2024 Nov 8.PMID: 39520984 No abstract available.

Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord. Tuddenham JF, Fujita M, Khairallah A, Harbison C, Flowers XE, Coronas-Samano G, Maniatis S, Daly A, Schneider JA, Teich AF, Vonsattel JPG, Sims PA, Elyaman W, Bradshaw EM, Phatnani H, Shneider N, Bennett DA, De Jager PL, Przedborski S, Menon V, Olah M. bioRxiv [Preprint]. 2024 Nov 14:2024.11.12.623183. doi: 10.1101/2024.11.12.623183.PMID: 39605399 Free PMC article. Preprint.

Balancing neuronal death. Prunell GF, Troy CM.  J Neurosci Res. 2004 Oct 1;78(1):1-6. doi: 10.1002/jnr.20252. PMID: 15372573.

Genome-wide scan of Flortaucipir PET levels finds JARID2 associated with cerebral tau deposition. Gunasekaran TI, Meena D, Lee AJ, Wu S, Dumitrescu L, Sperling R, Hohman TJ; Alzheimer’s Disease Neuroimaging Initiative; A4 Study; Huang J, Dehghan A, Tzoulaki I, Mayeux R, Vardarajan B.medRxiv [Preprint]. 2024 Oct 7:2024.10.04.24314853. doi: 10.1101/2024.10.04.24314853.PMID: 39417126 Free PMC article. Preprint.

CD33 and SHP-1/PTPN6 Interaction in Alzheimer's Disease. Beckers L, Rashid M, Lee AJ, Chatila ZK, Tamucci KA, Talcoff RC, Hall JL, Bennett DA, Vardarajan BN, Bradshaw EM. Genes (Basel). 2024 Sep 13;15(9):1204. doi: 10.3390/genes15091204.PMID: 39336795 Free PMC article.

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. Tayran H, Yilmaz E, Bhattarai P, Min Y, Wang X, Ma Y, Wang N, Jeong I, Nelson N, Kassara N, Cosacak MI, Dogru RM, Reyes-Dumeyer D, Stenersen JM, Reddy JS, Qiao M, Flaherty D, Gunasekaran TI, Yang Z, Jurisch-Yaksi N, Teich AF, Kanekiyo T, Tosto G, Vardarajan BN, İş Ö, Ertekin-Taner N, Mayeux R, Kizil C.Cell Genom. 2024 Sep 11;4(9):100642. doi: 10.1016/j.xgen.2024.100642. Epub 2024 Aug 30.PMID: 39216475 Free PMC article.

Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups. Ma Y, Reyes-Dumeyer D, Piriz A, Recio P, Mejia DR, Medrano M, Lantigua RA, Vonsattel JPG, Tosto G, Teich AF, Ciener B, Leskinen S, Sivakumar S, DeTure M, Ranjan D, Dickson D, Murray M, Lee E, Wolk DA, Jin LW, Dugger BN, Hiniker A, Rissman RA, Mayeux R, Vardarajan BN. Acta Neuropathol. 2024 Aug 23;148(1):27. doi: 10.1007/s00401-024-02778-y.PMID: 39177846 Free PMC article.

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development. Van Tartwijk FW, Wunderlich LCS, Mela I, Makarchuk S, Jakobs MAH, Qamar S, Franze K, Kaminski Schierle GS, St George-Hyslop PH, Lin JQ, Holt CE, Kaminski CF. J Neurosci. 2024 Jul 3;44(27):e2148232024. doi: 10.1523/JNEUROSCI.2148-23.2024.PMID: 38692734 Free PMC article.

Multi-target drugs for Alzheimer's disease. Turgutalp B, Kizil C. Trends Pharmacol Sci. 2024 Jul;45(7):628-638. doi: 10.1016/j.tips.2024.05.005. Epub 2024 Jun 9.PMID: 38853102 Review.

Rare genetic variation in Fibronectin 1 (FN1) protects against APOEe4 in Alzheimer's disease.
Bhattarai P, Gunasekaran TI, Reyes-Dumeyer D, Jülich D, Tayran H, Yilmaz E, Flaherty D, Lantigua R, Medrano M, Rivera D, Recio P, Ertekin-Taner N, Teich AF, Dickson DW, Holley S, Mayeux R, Kizil C, Vardarajan BN.bioRxiv [Preprint]. 2024 Jan 2:2024.01.02.573895. doi: 10.1101/2024.01.02.573895. Update in: Acta Neuropathol. 2024 Apr 10;147(1):70. doi: 10.1007/s00401-024-02721-1PMID: 38260431 Free PMC article. Preprint.

 Understanding the endo-lysosomal network in neurodegeneration. Cullen PJ, Holstege H, Small SA, St George-Hyslop P. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220372. doi: 10.1098/rstb.2022.0372. Epub 2024 Feb 19.PMID: 38368931 Free PMC article. No abstract available.

Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S; Long‐Life Family Study (LLFS); Alzheimer's Disease Genetic Consortium (ADGC); Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS). Alzheimers Dement. 2024 Apr;20(4):2670-2679. doi: 10.1002/alz.13718. Epub 2024 Feb 21.PMID: 38380866 Free PMC article.

Caghan Kizil, PhD, MSc 
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Annie J. Lee, PhD 
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Scott A. Small, MD 
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Badri N. Vardarajan, PhD, MS 
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