Annie J. Lee, PhD

Dr. Lee is a biostatistician by training, and her research focuses on understanding the genetic and molecular heterogeneity of Alzheimer’s disease, with particular emphasis on the role of cardio-cerebrovascular risk factors. Her group investigates how vascular comorbidities interact with genetic and molecular pathways by integrating genetics, bulk and single-cell transcriptomics, proteomics, epigenetics, metabolomics, and blood-based biomarkers. Dr. Lee applies advanced statistical genetics, machine learning, and multi-omics integration approaches to identify biologically meaningful subtypes of aging and Alzheimer’s disease. She is an integral member of the Alzheimer’s Disease Sequencing Project (ADSP) Phenotype Harmonization Consortium, leading efforts to harmonize vascular risk factors across multiple cohorts. Dr. Lee’s work aims to elucidate neurovascular mechanisms, advance early detection, and support precision medicine approaches for Alzheimer’s disease and related disorders.