Our Publications
Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model
https://doi.org/10.1002/alz.13699
Samantha M Rossano, Aubrey Sperling Johnson, Anna Smith, Galen Ziaggi, Andrew Roetman, Diana Guzman, Amarachukwu Okafor, Julia Klein, Zeljko Tomljanovic, Yaakov Stern, Adam M Brickman, Seonjoo Lee, William C Kreisl, Patrick Lao
Alzheimer's & Dementia (2024)
Microglial Activation, but Not Tau Pathology, Is Independently Associated With Amyloid Positivity and Memory Impairment
DOI: 10.1016/j.neurobiolaging.2019.09.019
Zou, James, Sha Tao, Aubrey Sperling Johnson, Zeljko Tomljanovic, Krista Polly, Julia Klein, Qolamreza R. Razlighi et al.
Neurobiology of Aging 85 (2020): 11-21.
Untangling the Relationship Between Microglia and Tau in Alzheimer's Disease
DOI: 10.1016/j.tins.2021.10.002
Rossano, Samantha M., and William Charles Kreisl.
Trends in Neurosciences 44, no. 12 (2021): 927-929.
Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease
DOI: 10.3233/JAD-201149
Klein, Julia, Xinyu Yan, Aubrey Sperling Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S. Honig et al. "Olfactory impairment is related to tau pathology and neuroinflammation in Alzheimer’s disease."
Journal of Alzheimer's Disease 80, no. 3 (2021): 1051-1065.
Deep Learning Improves Utility of Tau PET in the Study of Alzheimer's Disease
DOI: 10.1002/dad2.12264
Zou, James, David Park, Aubrey Sperling Johnson, Zeljko Tomljanovic, Davangere P. Devanand, Jose Luchsinger, Adam M. Brickman, William Charles Kreisl, and Frank Provenzano.
Alzheimer's & Dementia 17 (2021): e054310.
Patterns of Tau Pathology Identified With 18 F-MK-6240 PET Imaging
DOI: 10.1002/alz.12384
Kreisl, William Charles, Patrick J. Lao, Aubrey Sperling Johnson, Zeljko Tomljanovic, Julia Klein, Krista Polly, Benjamin Maas et al.
Alzheimer's & Dementia 18, no. 2 (2022): 272-282.
Posters & Abstracts
Validating noninvasive techniques for [11C]ER176 PET quantification in controls and Alzheimer’s disease patients
Samantha M. Rossano, Daniel Talmasov, Aubrey S. Johnson, Anna C. Smith, Diana S. Guzmán, Amarachukwu Okafor,William C. Kreisl, Philip L. De Jager, Patrick J. Lao
![](https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_200/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=EOjv54OH 200w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_260/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=Hi4Ptgf2 260w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_320/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=SfgTXjm_ 320w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_400/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=rwWTx13f 400w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_520/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=E_9f74eL 520w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_640/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=BYQ2Wts9 640w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_800/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=Sr8BjzE- 800w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=ph5P-x15 1040w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=m4LusZ8B 1280w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/general/2023-07/rsz_1rossano_aaic2023_poster_to_submit_070723.jpg?itok=CK1yLxqC 1600w)
Discovering Correlates of Off-Target 18F-MK6240 Signal in Community-Dwelling Adults
Aubrey S. Johnson, Amarachukwu Okafor, James Zou, Anna Smith, Diana S. Guzmán, William C. Kreisl, Adam M. Brickman, José A. Luchsinger, Patrick J. Lao
![](https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_200/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=rmoa4u-5 200w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_260/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=F2NPKhee 260w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_320/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=5ODFZvZC 320w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_400/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=YBOiOzkj 400w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_520/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=N-GuP4yJ 520w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_640/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=HqbB_LFZ 640w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_800/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=7rSWpN3i 800w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=5i7pKxdt 1040w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=boP5spEj 1280w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/general/2023-07/resized_johnsonas_mk6240_offtarget_aaic23_poster_7jul23_0.jpg?itok=9Z-uq6tv 1600w)
Elevated Tau burden in Amygdala and Hippocampus amongst older participants with psychosis
Aubrey S. Johnson, Galen Ziaggi, Hannah M. Houlihan, Anna C. Smith, Diana S. Guzmán, Amarachukwu Okafor, Edward D. Huey, William C. Kreisl, Daniel Talmasov, Patrick J. Lao
![](https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_200/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=NqrCRcNv 200w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_260/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=rr2KwehH 260w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_320/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=rJfTovbP 320w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_400/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=wBMvbrW1 400w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_520/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=5AbJZ-s4 520w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_640/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=IgWSX0ZE 640w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_800/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=YMjvrUMd 800w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=9XQ2XViQ 1040w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=TsqKz8Q7 1280w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/general/2023-07/psychosis_and_tau_poster-7jul23_asj_0.jpg?itok=wBRUIMW- 1600w)
Tau burden is associated with sleep disordered breathing in adults with Down syndrome
Anna Smith, Sigan Hartley, David T. Plante, Aubrey S. Johnson, Diana S. Guzmán, Amarachukwu Okafor, Samantha Rossano, Dana Tudorascu, Adam M. Brickman, Bradley T. Christian, Ozioma Okonkwo, Beau Ances, Annie Cohen, Benjamin L. Handen, Patrick Lao
![](https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_200/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=ROEv_I6V 200w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_260/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=K2J0Ole7 260w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_320/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=IPah7yQD 320w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_400/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=XrvOIJ8e 400w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_520/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=l_BVchqQ 520w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_640/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=8hDnW_Ft 640w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_800/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=M7x4RTDf 800w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=luEZOWwY 1040w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=hruNdKLW 1280w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/general/2023-07/aaic2023_sleep_tau_poster_final.jpg?itok=8yUjClQC 1600w)
Moderate alcohol use, total brain volume, and white matter hyperintensities among racially and ethnically diverse middle-aged adults
Diana S. Guzmán, Miguel Arce Rentería, Justina F. Avila, Indira C. Turney, Samantha M. Rossano, Aubrey Sperling Johnson, Anna C. Smith, Amarachukwu Okafor, Clarissa Morales, Yian Gu, Jennifer J. Manly, Adam M. Brickman, Patrick J. Lao
![](https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_200/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=07iqvNwr 200w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_260/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=z0qg7Roi 260w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_320/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=8KE1JrYw 320w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_400/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=_4Ly2eW7 400w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_520/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=Z9fl1dTi 520w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_640/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=9Pi7xW6h 640w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_800/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=jau0V63O 800w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=3Th3RzYM 1040w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=ODsITQDK 1280w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/general/2023-07/aaic2023_eposter_mod_alc_1.jpg?itok=sk-F3Tvl 1600w)
Psychosis and tau burden in older adults
Aubrey S. Johnson*, Galen Ziaggi*, Anna Smith, Edward D. Huey,William C. Kreisl, Daniel Talmasov, Patrick Lao
*These authors contributed equally
![](https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_200/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=33vdDgl_ 200w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_260/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=R6HqYyAB 260w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_320/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=hR1d3Hk- 320w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_400/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=HmlNKCQx 400w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_520/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=4Y5qCbSc 520w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_640/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=Z8F5M97K 640w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_800/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=t33jF-Hv 800w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=o16jY-dq 1040w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=62on87Ye 1280w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/general/2023-07/psychtau_poster_5jan2023_final_difffont_0.jpg?itok=FJzvgk4Z 1600w)
Differential properties of Early vs. Late 18F-Florbetaben imaging acquisition time frames
Aubrey S. Johnson, Anna C. Smith, Zeljko Tomljanovic, Galen Ziaggi, Andrew E. Roetman, Julia Klein, Richard Keegan, Lawrence S Honig, William Charles Kreisl
Abstract: DOI:10.1002/alz.067766
![](https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_200/public/media/general/2023-07/microsoftteams-image_4.png?itok=tLK0rxdE 200w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_260/public/media/general/2023-07/microsoftteams-image_4.png?itok=JtTcrhAQ 260w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_320/public/media/general/2023-07/microsoftteams-image_4.png?itok=KBH78qAW 320w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_400/public/media/general/2023-07/microsoftteams-image_4.png?itok=G253dzn- 400w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_520/public/media/general/2023-07/microsoftteams-image_4.png?itok=AdlRvaE5 520w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_640/public/media/general/2023-07/microsoftteams-image_4.png?itok=u8kB6ZXY 640w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_800/public/media/general/2023-07/microsoftteams-image_4.png?itok=V0VU7p4x 800w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/general/2023-07/microsoftteams-image_4.png?itok=LtscXHh6 1040w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/general/2023-07/microsoftteams-image_4.png?itok=DevxyAPV 1280w, https://www.neurology.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/general/2023-07/microsoftteams-image_4.png?itok=yiNeI-3J 1600w)