Develop and utilize innovative approaches to expand the phenotypically and genetically well-characterized NIA-LOAD FBS cohort through expanded recruitment of offspring and other family members, and longitudinal follow-up. Ascertain antecedent risk factors, particularly those related to cardio- and cerebrovascular diseases.
Implement novel approaches to recruit new and more ethnically diverse, multiplex LOAD families, focusing on African Americans, Mexican Americans, and Caribbean Hispanics residing in the United States.
Expand the range of blood-based biospecimens (DNA, RNA and brain tissue) in NIA-LOAD FBS families to support biomarker assays and functional genomic studies widely used in genetic research. In selected families with validated and confirmed mutation, collect peripheral blood mononuclear cells (PBMCs) for additional studies.
Continue to promote and coordinate voluntary brain donation among the NIA-LOAD FBS cohort to support vital neuropathological and functional genomic studies on Alzheimer’s disease and other neurodegenerative disorders.
Expand and continue to facilitate the sharing of clinical, genetic, and biospecimen resources to the research community from the NIA-LOAD FBS.