Clinical Trials
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Principal Investigator:
Jennifer M. Bain, MD, PhDThe purpose of this study is to investigate the long-term safety, effectiveness, and tolerability of Radiprodil, which is an investigational drug for the treatment of GRIN related Neurodevelopmental Disorder (GRIN-NDD). The study is broken up into 2 parts: Part A, which includes Screening, Medication Titration, and Maintenance periods and lasts 20-35 weeks, and Part B, which includes a 4-6 week transition titration period and an open label treatment period of at least 2 years. During Part A, half of the participants will receive Radiprodil, and half will receive a placebo (inactive) drug... -
Principal Investigator:
Adam M. Brickman, PhDThank you for your interest in our research! We are studying how life experiences impact brain health and memory in people with and without HIV. Your participation can help advance science and improve future care. What's involved? You'll come to the Columbia University Irving Medical Center for a one-time visit, which includes a blood draw, urine test, and vitals, a brain MRI, memory testing, and surveys about your health and experiences. What's in it for you? You will receive up to $200 compensation for completing the visit, and get access to some of your clinical results. Most importantly,... -
Principal Investigator:
Jason Brant Carmel, MD, PhDThe Weinberg Family Cerebral Palsy Center's (WFCPC) research team maintains a cerebral palsy (CP) patient registry of more than 1,000 enrolled patients. This registry contains information collected from children and adults with CP. The goal of the registry is to help us learn more about CP and neuromuscular diseases, to understand the quality of life of patients with these diseases, and to study different treatment and surgical options. The registry allows our researchers to capture a more complete picture than ever of the full scope of patients living with CP and to investigate long-term... -
Principal Investigator:
Sloane Heller, MDThe purpose of this study is to understand how liver disease affects thinking and memory, both before and after transplant. Participants will take a cognitive test, which will be a series of tasks and questions similar to a video game, at home on their own computers, tablets, or phones. This will take approximately 45 minutes, and participants will do this once a year for 3 years. We will assess how thinking and memory changes over time and in response to transplant. -
Principal Investigator:
Rebecca Straus Farber, MDWe need your help today to gather information about the experience of patients with autoimmune diseases of the central nervous system (multiple sclerosis (MS), neuromyelitis optica (NMO), and anti-MOG associated disease (MOGAD)) in regards to COVID19 vaccines. Because individuals with MS, NMO, and MOGAD were not included in the COVID19 vaccine trials, we want to learn more about the experience of individuals with these autoimmune diseases and the vaccine. Because many patients with central nervous system autoimmune disease also take medications that affect the immune system, we want to find... -
Principal Investigator:
Philip L. De Jager, MD, PHDThe Snapshot study aims to understand brain and spinal cord aging in healthy individuals and individuals with multiple sclerosis (MS). We aim to identify new tools that will help us to achieve successful brain aging in the general population and in people with an underlying autoimmune disease. A critical aspect of this study is that we are looking for individuals who are willing to donate their brain and spinal cord when they pass away; this will enable the investigators to understand which molecules in the brain made someone more or less likely to age successfully. The brains will be housed... -
Principal Investigator:
Sheng-Han Kuo, MDParticipate in learning more about Impulsivity and Compulsivity in Spinocerebellar ataxia (SCA). By investigating individuals with SCA, we will gain valuable insights into the specific mechanisms through which the cerebellum participates in cognitive processes. Eligible participants: Adults over the age of 18, diagnosed with Spinocerebellar ataxia (SCA) and healthy adults over the age of 18, who would like to participate as controls. Participation involves one clinic visit for 3-4 Hours, involving cognitive baseline measurements, and functional magnetic resonance imaging (fMRI) recording... -
Principal Investigator:
Jason Brant Carmel, MD, PhDA key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries. -
Principal Investigator:
Philip L. De Jager, MD, PHDWe're testing a new type of MRI scanner that's smaller and portable - like a mobile MRI unit. This makes it easier to provide brain scans to people who have difficulty traveling to hospitals or live far from medical centers. We'll be studying people with multiple sclerosis (MS) and similar brain conditions. Our goal is to learn how well this portable scanner can measure brain changes and how these changes relate to memory and thinking abilities. By validating this technology, we hope to make MRI scanning more accessible to everyone while advancing our understanding of conditions like MS. The... -
Principal Investigator:
Philip L. De Jager, MD, PHDThe Snapshot study aims to understand brain and spinal cord aging in healthy individuals and individuals with multiple sclerosis (MS). We aim to identify new tools that will help us to achieve successful brain aging in the general population and in people with an underlying autoimmune disease. A critical aspect of this study is that we are looking for individuals who are willing to donate their brain and spinal cord when they pass away; this will enable the investigators to understand which molecules in the brain made someone more or less likely to age successfully. The brains will be housed...