Clinical Trials

  • Efficacy and Safety of Nipocalimab in Patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    Principal Investigator:

    Thomas H. Brannagan III, MD
    This is a multicenter, Phase 2/3 study to Evaluate the Efficacy and Safety of Nipocalimab Administered to Adults with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Adults 18 yrs old or greater at the time of signing the informed consent.

  • Genetic Variants of Microglial Activation in AD

    Principal Investigator:

    Philip L. De Jager, MD, PHD
    The purpose of this study is to determine whether different genes are related to the amount of immune cell activity that occurs in the brain in patients with Alzheimer's disease. Participation in this study involves memory testing, a blood draw, MRI, and three PET scans. The second PET scan will involve putting a catheter in your wrist to draw blood during the scan. You will be compensated $700. After one year or so, we will invite you back to repeat some tests.

  • Genetic Variants of Microglial Activation in AD (Healthy Volunteers)

    Principal Investigator:

    Philip L. De Jager, MD, PHD
    The purpose of this study is to determine whether different genes are related to the amount of immune cell activity that occurs in the brain in patients with Alzheimer's disease. Participation in this study involves memory testing, a blood draw, MRI, and three PET scans. The second PET scan will involve putting a catheter in your wrist to draw blood during the scan. You will be compensated $700. After one year or so, we will invite you back to repeat some tests.

  • Healthy Brain Donation Project - Brain Bank

    Principal Investigator:

    Philip L. De Jager, MD, PHD
    The Snapshot study aims to understand brain and spinal cord aging in healthy individuals and individuals with multiple sclerosis (MS). We aim to identify new tools that will help us to achieve successful brain aging in the general population and in people with an underlying autoimmune disease. A critical aspect of this study is that we are looking for individuals who are willing to donate their brain and spinal cord when they pass away; this will enable the investigators to understand which molecules in the brain made someone more or less likely to age successfully. The brains will be housed...

  • Impulsivity and Compulsivity in Spinocerebellar ataxia (SCA) - Healthy Controls

    Principal Investigator:

    Sheng-Han Kuo, MD
    Why? By investigating individuals with SCA, we will gain valuable insights into the specific mechanisms through which the cerebellum participates in cognitive processes. Who? Healthy adults over the age of 18, who would like to participate as controls. What? Participation involves one clinic visit for 3-4 Hours, involving cognitive baseline measurements, an electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recording during which a decision-making two-step task will be performed. Cost to me? There is no cost involved for participating in the study. You will receive...

  • MS Snapshot: A Study to Better Understand Multiple Sclerosis

    Principal Investigator:

    Philip L. De Jager, MD, PHD
    The Snapshot study aims to understand brain and spinal cord aging in healthy individuals and individuals with multiple sclerosis (MS). We aim to identify new tools that will help us to achieve successful brain aging in the general population and in people with an underlying autoimmune disease. A critical aspect of this study is that we are looking for individuals who are willing to donate their brain and spinal cord when they pass away; this will enable the investigators to understand which molecules in the brain made someone more or less likely to age successfully. The brains will be housed...

  • Multiple Sclerosis (MS) Genetics

    Principal Investigator:

    Philip L. De Jager, MD, PHD
    MS Genetics aims to better understand the genetic component of demyelinating diseases by doing genetic testing on blood samples of participants. This study involves a one-time blood draw and completion of questionnaires spread out over a couple of years in hopes to better understand the genes that makes one predisposed to Multiple Sclerosis and various other demyelinating diseases.

  • New IDEAS: Brain Imaging Study for Memory Loss

    Principal Investigator:

    Lawrence Sterling Honig, MD, PhD
    This is a research study for persons with memory problems that examines the utility of performing positron emission tomography (PET) scans for the brain amyloid protein found in Alzheimer's disease.

  • New IDEAS: Brain Imaging Study for Memory Loss

    Principal Investigator:

    Lawrence Sterling Honig, MD, PhD
    This is a research study for persons with memory problems that examines the utility of performing positron emission tomography (PET) scans for the brain amyloid protein found in Alzheimer's disease.

  • Parkinson's Progression Markers Initiative (PPMI)

    Principal Investigator:

    Sarah A. O'Shea, MD
    The Parkinson's Progression Markers Initiative (PPMI) seeks to uncover insights into Parkinson's disease (PD) onset and progression that could transform how we diagnose, treat, and potentially prevent PD. PPMI has already contributed to a new understanding around disease biology and experience, and its findings and design have led to more efficient clinical research. Now PPMI is looking to bring together a larger and more diverse group of individuals both with and without PD who can help contribute to a more detailed look into the way the disease develops and changes over time. The study will...

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