Publications

• Cottarelli A, Shahriar S, Arac A, Glendinning M, Tuohy MC, Prochilo G, Neal JB, Edinger AL, Agalliu D. Rab7a activation promotes degradation of select tight junction proteins at the blood-brain barrier after ischemic stroke. bioRxiv 2023 Aug 29;555373. doi: https://doi.org/10.1101/2023.08.29.555373

• Biswas S, Shahriar S, Bachay G, Arvanitis P, Jamoul D, Brunken WJ, Agalliu D. Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling. Neuron. 2024 Jun 19;112(12):1978-1996. doi: 10.1016/j.neuron.2024.03.011. 

• Wayne CR, Bremner L, Faust TE, Duran-Laforet V, Ampatey N, Ho SJ, Feinberg PA, Arvanitis P, Ciric B, Ruan C, Elyaman W, Delaney SL, Vargas WS, Swedo S, Menon V, Schafer DP, Cutforth T, Agalliu D. Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis. bioRxiv 2023 Mar 10;532135. doi: https://doi.org/10.1101/2023.03.10.532135

• Shahriar S, Price MZ, Wayne CR, Glendinning MD, Prochilo G, Stuhlman H, Biswas S, Menon V, Agalliu D. Single-cell RNA sequencing implicates venous endothelial cells as a source of VEGF-mediated neo-angiogenesis in neuroinflammation. bioRxiv 2022 Nov 15;516660. doi: https://doi.org/10.1101/2022.11.15.516660

• Garretti F, Monahan C, Sloan N, Bergen J, Shahriar S, Kim SW, Sette A, Cutforth T, Kanter E, Agalliu D, Sulzer D. Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's disease. Neuron. 2023 Aug 11:S0896-6273(23)00548-2. doi: 10.1016/j.neuron.2023.07.015. Epub ahead of print. PMID: 37597517.

• Tuohy MC, Hillman EMC, Marshall R, Agalliu D. The age-dependent immune response to ischemic stroke. Curr Opin Neurobiol. 2023 Feb;78:102670. doi: 10.1016/j.conb.2022.102670. Epub 2022 Dec 29.

• Biswas S, Shahriar S, Giangreco NP, Arvanitis P, Winkler M, Tatonetti NP, Brunken WJ, Cutforth T, Agalliu D. Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation. Development. 2022 Sep 1;149(17):dev200610. doi: 10.1242/dev.200610.

• Cottarelli A, Wayne CR, Agalliu D, Biswas S, The neurovascular unit and blood–CNS barriers in health and disease, in The Vasculome: From Many, One, Z. Galis, Editor. 2022, Elsevier Science, p. 111-125, doi: 10.1016/B978-0-12-822546-2.00023-X.

• Boyé K, Geraldo LH, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, Nelson B, Xu Y, Jacob L, Maissa N, Agalliu D, Claesson-Welsh L, Ackerman SL, Eichmann A. Endothelial Unc5B controls blood-brain barrier integrity. Nat Commun. 2022 Mar 4;13(1):1169. doi: 10.1038/s41467-022-28785-9.

• Garretti F, Monahan C, Sette A, Agalliu D, Sulzer D. T cells, α-synuclein and Parkinson disease. Handb Clin Neurol. 2022;184:439-455. doi: 10.1016/B978-0-12-819410-2.00023-0.

• Yang JM, Moon SY, Lee JY, Agalliu D, Yon DK, Lee SW. COVID-19 morbidity and severity in patients with age-related macular degeneration: a Korean nationwide cohort study. Am J Ophthalmol. 2021 Jun 5:11881. doi: 10.1016/j.ajo.2021.05.024.

• Genestine M, Ambriz D, Crabtree GW, Dummer P, Molotkova A, Quintero M, Mela A, Biswas S, Feng H, Zhang C, Canoll P, Hargus G, Agalliu D, Gogos JA, Au E. Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons. Elife. 2021 Apr 27;10:e56063.

• Thakur KT, Miller EH, Glendinning MD, Al-Dalahmah O, Banu MA, Boehme AK, Boubour AL, Bruce SS, Chong AM, Claassen J, Faust PL, Hargus G, Hickman RA, Jambawalikar S, Khandji AG, Kim CY, Klein RS, Lignelli-Dipple A, Lin CC, Liu Y, Miller ML, Moonis G, Nordvig AS, Overdevest JB, Prust ML, Przedborski S, Roth WH, Soung A, Tanji K, Teich AF, Agalliu D, Uhlemann AC, Goldman JE, Canoll P. COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital. Brain. 2021 Apr 15:awab148.

• Lu TM, Houghton S, Magdeldin T, Durán JGB, Minotti AP, Snead A, Sproul A, Nguyen DT, Xiang J, Fine HA, Rosenwaks Z, Studer L, Rafii S, Agalliu D, Redmond D, Lis R. (2021) Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate. Proc Natl Acad Sci U S A. Feb 23;118(8):e2016950118.

• Song S, Huang H, Guan X, Fiesler V, Bhuiyan MIH, Liu R, Jalali S, Hasan MN, Tai AK, Chattopadhyay A, Chaparala S, Sun M, Stolz DB, He P, Agalliu D, Sun D, Begum G. (2021) Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke. Prog Neurobiol. Apr;199:101963.

• Cottarelli A, Corada M, Beznoussenko GV, Mironov AA, Globisch MA, Biswas S, Huang H, Dimberg A, Magnusson PU, Agalliu D, Lampugnani MG, Dejana E. (2020) Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development. Aug 24;147(16):dev185140

• Jury D, Daugaard I, Sanders KJ, Hansen LL, Agalliu D, Pedersen IM. (2020) miR-151a enhances Slug dependent angiogenesis. Oncotarget. Jun 9;11(23):2160-2171.

• Biswas S, Cottarelli A, Agalliu D. (2020) Neuronal and glial regulation of CNS angiogenesis and barriergenesis. Development. May 1;147(9):dev182279.

• Platt MP, Bolding KA, Wayne CR, Chaudhry S, Cutforth T, Franks KM, Agalliu D. (2020) Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis. Proc Natl Acad Sci U S A. Mar 24;117(12):6708-6716.

• Benbenishty A, Gadrich M, Cottarelli A, Lubart A, Kain D, Amer M, Shaashua L, Glasner A, Erez N, Agalliu D, Mayo L, Ben-Eliyahu S, Blinder P. (2019) Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation. PLoS Biol. Mar 28;17(3):e2006859.

• Garretti F, Agalliu D, Lindestam Arlehamn CS, Sette A, Sulzer D. (2019) Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells. Front Immunol. Feb 25;10:303.

• Das S, Goldstone AB, Wang H, Farry J, D'Amato G, Paulsen MJ, Eskandari A, Hironaka CE, Phansalkar R, Sharma B, Rhee S, Shamskhou EA, Agalliu D, de Jesus Perez V, Woo YJ, Red-Horse K. (2019) A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration. Cell. Feb 21;176(5):1128-1142.e18

• Miller EC, Sundheim KM, Willey JZ, Boehme AK, Agalliu D, Marshall RS. (2018) The Impact of Pregnancy on Hemorrhagic Stroke in Young Women. Cerebrovasc Dis. 2018;46(1-2):10-15.

• Liebner S, Dijkhuizen RM, Reiss Y, Plate KH, Agalliu D, Constantin G. (2018) Functional morphology of the blood-brain barrier in health and disease. Acta Neuropathol. Mar;135(3):311-336.

• Lutz SE, Smith JR, Kim DH, Olson CVL, Ellefsen K, Bates JM, Gandhi SP, Agalliu D. (2017) Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation. Cell Rep. Nov 21;21(8):2104-2117.

• Mazzoni J, Smith JR, Shahriar S, Cutforth T, Ceja B, Agalliu D. (2017) The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels. Neuron. Dec 6;96(5):1055-1069.e6.

• Daugaard I, Sanders KJ, Idica A, Vittayarukskul K, Hamdorf M, Krog JD, Chow R, Jury D, Hansen LL, Hager H, Lamy P, Choi CL, Agalliu D, Zisoulis DG, Pedersen IM. (2017) miR-151a induces partial EMT by regulating E-cadherin in NSCLC cells. Oncogenesis. Jul 31;6(7):e366.

• Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. (2017) Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Cell Rep. 19(7):1365-1377.

• Platt MP, Agalliu D, Cutforth T. (2017) Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis. Front Immunol. 8:442.

• Lengfeld JE, Lutz SE, Smith JR, Diaconu C, Scott C, Kofman SB, Choi C, Walsh CM, Raine CS, Agalliu I, Agalliu D. (2017) Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis. Proc Natl Acad Sci USA. 114(7):E1168-E1177.

• Paul D, Baena V, Ge S, Jiang X, Jellison ER, Kiprono T, Agalliu D, Pachter JS. (2016) Appearance of claudin-5⁺ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. J Neuroinflammation. 13(1):292.

• Cutforth T, DeMille MM, Agalliu I, Agalliu D. (2016) CNS autoimmune disease after Streptococcus pyogenes infections: animal models, cellular mechanisms and genetic factors. Future Neurol. 11(1):63-76.

• Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.  (2016) Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 10:46.

• Dileepan T, Smith ED, Knowland D, Hsu M, Platt M, Bittner-Eddy P, Cohen B, Southern P, Latimer E, Harley E, Agalliu D, Cleary PP. (2016) Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells. J Clin Invest. 126(1):303-17.

• Mazzoni J, Cutforth T, and Agalliu D. (2015). Dissecting the role of smooth muscle cells versus pericytes in regulating cerebral blood flow using in vivo optical imaging. Neuron. 87(1): 4-6.

• Kurimoto S, Jung J, Tapadia M, Lengfeld J, Agalliu D, Waterman M, Mozaffar T, and Gupta R. (2015). Activation of the Wnt/β-catenin signaling cascade after traumatic nerve injury. Neuroscience. 294:101-8.

• Lengfeld J, Cutforth T, and Agalliu D. (2014). The role of angiogenesis in the pathology of multiple sclerosis. Vascular Cell. 6(1):23.

• Knowland D., Arac A., Sekiguchi K.J., Hsu M., Lutz S.E., Perrino J., Steinberg G.K., Barres B.A., Nimmerjahn A., and Agalliu D (2014). Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. Neuron. 82(3):603-617.

• Lutz S.E., Lengfeld J., and Agalliu D (2014). Stem cell-based therapies for multiple sclerosis: recent advances in animal models and human clinical trials. Regenerative Medicine. 9(2):129-132.

• Liu L, Eckert MA, Riazifar H, Kang DK, Agalliu D, Zhao W (2013). From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier? Stem Cells Int. 2013:435093.

• Liu S, Agalliu D, Yu C, Fisher M (2012). The role of pericytes in blood-brain barrier function and stroke. Curr Pharm Des.  18(25):3653-62.

• Shimomura Y*, Agalliu D*, Vonica A*, Luria V*, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA and Christiano AM (2010). APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature. 464(7291):1043-1047.

• Daneman R, Rumah KR, Zhou L, Agalliu D, Cahoy JD, Kaushal A and Barres BA (2010). The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS One. 5(10):e13741.

• Emery B, Agalliu D, Cahoy JD, Watkins TA, Dugas JC, Mulinyawe SB, Ibrahim A, Ligon KL, Rowitch DH and Barres BA (2009). Myelin-gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell. 138(1):172-85.

• Agalliu D, Takada S, Agalliu I, McMahon AP and Jessell TM (2009). Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron. 61(5):708-720.

• Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ and Barres BA (2009). Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci USA. 106(15):641-646.

• Agalliu D and Schieren I (2009). Heterogeneity in the developmental potential of motor neuron progenitors revealed by clonal analysis of single cells in vitro. Neural Development 4:2.

• Masckauchan, NTH, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li C, Khoo A, Tycko B, Brown AM and Kitajewski J (2006). Wnt5a signaling induces proliferation and survival of endothelial cells and expression of MMP-1 and Tie-2. Molecular Biology of the Cell 17:5163-72.

• Lieberam I*, Agalliu D*, Nagasawa T, Ericson J and Jessell TM (2005). A Cxcl12-Cxcr4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron 47:667-679.

*equal authorship