Lu Zeng, PhD

  • Associate Research Scientist in the Department of Neurology
Profile Headshot

Overview

Academic Appointments

  • Associate Research Scientist in the Department of Neurology

Languages

  • Chinese

Credentials & Experience

Education & Training

  • MPhil/MS (joint), 2014 The University of Adelaide and Shanghai Jiao Tong University, Shanghai, China
  • PhD, 2018 The University of Adelaide, Adelaide, Australia
  • Postdoctoral Fellow, 2021 Icahn School of Medicine at Mount Sinai, New York

Honors & Awards

  • National Multiple Sclerosis Society Biostatistics/Informatics Junior Faculty Award, 2025-2028
  • Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Young Investigator Educational Grant, 2025
  • ASHG Reviewer’s Choice Award, 2024

Research

Dr. Lu Zeng is a statistical geneticist whose research integrates statistical genetics, computational biology, and multi-omics to investigate the genetic and molecular mechanisms underlying neurological and autoimmune diseases, with a particular focus on multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease. Her research combines large-scale genome-wide association studies with single-cell genomics, transcriptomics, epigenomics, and proteomics to identify disease-associated cell types, genes, and molecular pathways. Her work aims to translate human genetic discoveries into biological insights that advance our understanding of disease mechanisms and inform the development of therapeutic strategies.

Selected Publications

Google Scholar publications

Selected Publications

  1. Zeng L*, Khan A*, Fitzgerald KC, et al. Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility. Nat Genet. 2026;58(9):2177-2191. doi:10.1038/s41588-026-02731-7.
  2. Fujita M*, Gao Z*, Zeng L*, et al. Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain. Nat Genet. 2024;56:605-614. doi:10.1038/s41588-024-01685-y.
  3. Zeng L, Fujita M, Gao Z, et al. A Single-Nucleus Transcriptome-Wide Association Study Implicates Novel Genes in Depression Pathogenesis. Biol Psychiatry. 2024;96(1):34-43. doi:10.1016/j.biopsych.2023.12.012.
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