Claassen Lab/Disorders of Consciousness Lab (DoC-Lab)

Location and Contact Information

177 Fort Washington Avenue
MHB, 8th-floor
New York, NY 10032
United States

Principal Investigator

  • Profile Headshot
    • Head of Neurocritical Care and Medical Director of the Neurological Intensive Care Unit
    • Chief, Critical Care and Hospitalist Neurology

Mission

Our mission is to develop accurate predictions of outcomes and to support the recovery process of unconscious critically ill patients. Applying machine learning algorithms, we focus on detecting covert consciousness in electrophysiological and imaging data of unresponsive patients and build prediction tools based on advanced statistical modeling. We aim to support the recovery process with innovative technology and work on brain computer interfaces to support communication with unresponsive patients.

Ongoing projects include:

  • Determining the behavioral phenotype of patients with covert consciousness
  • Elucidating the mechanistic underpinnings of covert consciousness using structural and functional MRI
  • Determining the impact of aphasia on the ability to detect command following in unconscious appearing patients
  • Investigating novel stimulation paradigms such as storytelling, music, and event related potentials to understand brain function in unresponsive appearing patients
  • Medication and physical therapy interventions to support recovery of consciousness
  • Brain computer interface development to connect to unresponsive appearing patients
  • Outcome expectations and technology acceptance in patients, families, and health care workers

Publications

For a complete list of publications, please visit PubMed.gov

Some People Who Appear to Be in a Coma May Actually Be Conscious. Scientific American 2022

‘It’s Gigantic’: A New Way to Gauge the Chances for Unresponsive Patients. New York Times. 2019

Alumni

  • Adu Mattory, BA
  • Andrey Eliseyev, PhD
  • Athina Vrosgou, MSc
  • Ayham Alkhachroum, MD
  • Benjamin Rohaut, MD, PhD
  • Brian Fidale, MD
  • Caroline Der Nigoghossian, PharmD
  • Eva Franzova, MD
  • Greer Waldrop, MD
  • Hans Peter Frey, PhD
  • Jennifer Egbebike, BA
  • Kevin Doyle, BA
  • Laruen Grobois, BA
  • Lizbeth Cespedes BSN, RN
  • Lucy Paniker, PA
  • Mariam Yazdl, RN
  • Wei-Ting Chiu, MD

Lab Members

  • Ángela G. Velázquez

    • Assistant Director, Clinical Research
    Angela Velazquez, MD
  • Qi Shen, PhD

    • Associate Research Scientist in the Department of Neurology; Data scientist and biostatistician
    Qi Shen, PhD
  • Jerina Carmona, MPH

    • Clinical Research Coordinator
    Jerina Carmona, MPH
  • Lucie Kruger, BS

    • Clinical Research Coordinator
    Lucie Kruger, BS
  • Satoshi Egawa, MD

    • Adjunct Associate Research Scientist in the Department of Neurology
    Satoshi Egawa, MD
  • Joshua Kahan, MD, PhD

    • Postdoctoral Clinical Fellow in the Department of Neurology
    Joshua Kahan, MD, PhD
  • Elizabeth Carroll, MD

    • Postdoctoral Clinical Fellow in the Department of Neurology
    Elizabeth Carroll, MD
  • Jeremy Ader, MD

    • Assistant in Clinical Neurology and Postdoctoral Residency Fellow in the Department of Neurology
    Jeremy Ader, MD
  • Sweta Patel, PA

    • Physician Assistant
    Patel Sweta
  • Ian J. Gonzalez, REEGT

    • Neurophysiology Technician
  • Gregory Heinonen, BS

    • Medical Student
  • Alexander T Morri, BS

    • Medical Student
  • Lorenzo Casertano, PT

    • Physical Therapist