Maoxue Tang, PhD

  • Assistant Professor of Neurological Science (in Neurology) at CUMC
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Overview

Research in my laboratory is focused on understanding the circuit, cellular and molecular mechanisms underlying the Glucose Transporter-1 deficiency syndrome (Glut1 DS). We use a combination of animal models as well as a wide range of genomic, molecular, and confocal imaging approaches to 1) investigate the role of SLC2A1 gene in brain cells, such as endothelial cells, astrocytes, and neurons; 2) determine the impact of low Glut1 protein on brain dysfunction; 3) discover genetic modifiers of disease pathways; 4) study how angiogenesis impairment impact synaptogenesis and astrocytic function in Glut1 deficient mice; 5) generate “humanized” Glut1 (SLC2A1) model mice - a key tool to test potential therapeutics. Our long-term goal is to develop the viable treatments for patients suffering from Glut1 DS.

Academic Appointments

  • Assistant Professor of Neurological Science (in Neurology) at CUMC

Credentials & Experience

Education & Training

  • 2006 Anhui Agricultural University, China
  • PhD, 2012 Chinese Academy of Agricultural Sciences

Research

Research Interests:

  • CNS Vascular Biology
  • Neuroimmunology
  • Neurobiology of Disease
  • Synapses and Circuits

For a complete list of publications, please visit PubMed.gov