Frank A. Provenzano, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Neurological Sciences (in Neurology in The Taub Institute)

Gender

  • Male

Credentials & Experience

Education & Training

  • BS, Biomedical Engineering, Columbia University
  • MSc, Biomedical Engineering, Columbia University
  • MPhil, Biomedical Engineering, Columbia University
  • PhD, Biomedical Engineering, Columbia University

Research

Dr. Provenzano’s research focuses primarily in the exploration of MRI methods in the domains of neurology and psychiatry. Specifically, using high resolution non-BOLD fMRI to interrogate small regions within the functionally defined areas of the brain, specifically the hippocampus. Using these high-resolution functional scans, one can apply detected dysfunction to characterize disease states and risk in Alzheimer’s disease, cognitive aging, schizophrenia and others to assess potential risk and therapeutic response. Since analogous techniques can be applied to animal models as well, this allows for translational measurements that can be detected in vivo, non-invasively, and cross-species.

Dr. Provenzano also focuses on large-scale data imaging analysis and imaging informatics. Specifically, obtaining, curating and repurposing existing clinical neuroimaging data and applying newer analytical tools and techniques to extract potentially useful biomarkers. This capitalizes on the availability and recent advances in machine learning methods and the computational infrastructure necessary to process.

Selected Publications

Brickman AM, Khan UA, Provenzano FA, Yeung LK, Suzuki W, Schroeter H, Wall M, Sloan RP, Small SA. Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat Neurosci. 2014 Dec;17(12):1798-803

Khan UA, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, Mayeux R, Duff KE, Small SA. Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.Nat Neurosci. 2014 Feb;17(2):304-11

Provenzano FA, Muraskin J, Tosto G, Narkhede A, Wasserman BT, Griffith EY, Guzman VA, Meier IB, Zimmerman ME, Brickman AM; Alzheimer's Disease Neuroimaging Initiative. White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease? JAMA Neurol. 2013 Apr;70(4):455-61.