Frank A. Provenzano, PhD

Dr. Provenzano's research focuses on developing and validating neuroimaging biomarkers across diverse disorders including neurodegeneration, multiple sclerosis, movement disorders, precision psychiatry, traumatic brain injury, autism, PTSD, and epilepsy. Drawing from his translational work in Alzheimer's disease, he develops methods in surface deformation, tissue analysis, and inherent topology with the goal of creating tools applicable to both clinical and research scans. He has pioneered explainable AI approaches for neuroimaging disease classification and developed high-resolution fMRI techniques to assess disease risk and therapeutic response. By leveraging clinical and research databases across disease types, he extracts quantitative biomarkers from routine imaging as well as advanced modalities like high-field MRI and molecular PET. His current work focuses heavily on democratizing AI-driven biomarker tools for broader clinical adoption and improve diagnostic accuracy.

Dr. Provenzano is an investigator at the Columbia University Alzheimer's Disease Research Center and the National Multiple Sclerosis Brain Bank, a PI of the NINDS-funded Access for All in ALS West Coordinating Center, and founded the Advanced Imaging Analysis Core for the Epilepsy Division. He leads neuroimaging efforts in the Stavros Niarchos Foundation Center for Precision Psychiatry and Mental Health, develops and teaches "Multimodal Neuroimaging" at the Fu Foundation School of Engineering and Applied Sciences, and is a member of the Data Science Institute. He has been a mentor to dozens of students and researchers, from local high school students to VP&S Dean’s Research Fellows. He holds several patents in neuroimaging and is active in entrepreneurship.