Gelinas Lab

Principal Investigator

Epilepsy is more than just seizures. Children and adults with epilepsy often experience problems with intellectual development, learning, memory, and attention – symptoms that can sometimes be even more disabling than seizures.

In our lab, we study neural networks that mediate these cognitive functions in developing and mature brains. By understanding the physiology of these networks and how they are disrupted by epileptic activity, we work toward targeted treatments that aim not only to stop seizures, but also to address cognitive comorbidities.

Research Areas

Epilepsy and Memory

We use memory tasks and large-scale neural recordings in behaving rodents to understand the interplay between epileptic activity and memory. We also use closed-loop technologies to perturb these neural networks with the goal of altering memory function.

Neurodevelomental Disorders

We perform multi-cortical neurophysiologic recordings in wild type neonatal and juvenile rodents as well as those harboring mutations associated with epilepsy, autism, and intellectual disability to understand the unique features of these neurodevelopmental disorders.

Devices and Computation for Epileptic Networks.

We develop computational approaches to interictal epileptic networks using intracranial EEG data from patients with epilepsy, and leverage advanced neural interface devices to gain higher spatiotemporal resolution data from these networks.

Select Publications

  • Cea C, Zhao Z, Wisniewski DJ, Spyropoulos GD, Polyravas A, Gelinas JN*, Khodagholy D* (2023) Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics. Nature Materials. 2023 Jul 10:1-9. PDF ​

  • Bernard C, Frauscher B, Gelinas J and Timofeev I (2023) Sleep, oscillations, and epilepsy. Epilepsia. PDF

  • Dahal P, Rauhala O, Khodagholy D*, Gelinas JN* (2023) Hippocampal–cortical coupling differentiates long-termmemory processes. PNAS, Vol. 120, No. 7. PDF

  •   Vitale F, Gelinas JN, Cabrera LY (2022) Neurotechnology: Bridging the dialogue between engineers, material scientists, clinicians, and ethicists. Iscience. Nov 18;25(11). PDF

  • Khodagholy D*, Ferrero JJ, Park J, Zhao Z, Gelinas JN* (2023) Large-scale, closed-loop interrogation of neural circuits underlying cognition. Trends in Neurosciences. Oct 26. PDF

  • Hassan AR, Zhao Z, Ferrero JJ, Cea C, Jastrzebska‐Perfect P, Myers J, Asman P, Ince NF, McKhann G, Viswanathan A, Sheth SA, Khodagholy D*, Gelinas JN* (2022) Translational organic neural interface devices at single neuron resolution. Advanced Science. Sep;9(27):2202306. PDF

  • Robinson JT*, Rommelfanger KS*, Anikeeva PO, Etienne A, French J, Gelinas J, Grover P, Picard R (2022) Building a culture of responsible neurotech: neuroethics as socio-technical challenges. Neuron. Jul 6;110(13):2057-62. PDF

  • Pouliopoulos AN, Murillo MF, Noel RL, Batts AJ, Ji R, Kwon N, Yu H, Tong CK, Gelinas JN, Araghy DK, Hussaini SA, Konofagou EE* (2022) Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation. Brain stimulation. Jul 1;15(4):927-41. PDF

  • Cea C, Zhao Z, Wisniewski DJ, Spyropoulos GD, Polyravas A, Gelinas JN*, Khodagholy D* (2023) Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics. Nature Materials. 2023 Jul 10:1-9. PDF ​ Bernard C, Frauscher B, Gelinas J and Timofeev I (2023) Sleep, oscillations, and epilepsy. Epilepsia. PDF ​ Dahal P, Rauhala O, Khodagholy D*, Gelinas JN* (2023) Hippocampal–cortical coupling differentiates long-termmemory processes. PNAS, Vol. 120, No. 7. PDF ​ Vitale F, Gelinas JN, Cabrera LY (2022) Neurotechnology: Bridging the dialogue between engineers, material scientists, clinicians, and ethicists. Iscience. Nov 18;25(11). PDF ​ Khodagholy D*, Ferrero JJ, Park J, Zhao Z, Gelinas JN* (2023) Large-scale, closed-loop interrogation of neural circuits underlying cognition. Trends in Neurosciences. Oct 26. PDF ​ Hassan AR, Zhao Z, Ferrero JJ, Cea C, Jastrzebska‐Perfect P, Myers J, Asman P, Ince NF, McKhann G, Viswanathan A, Sheth SA, Khodagholy D*, Gelinas JN* (2022) Translational organic neural interface devices at single neuron resolution. Advanced Science. Sep;9(27):2202306. PDF ​ Robinson JT*, Rommelfanger KS*, Anikeeva PO, Etienne A, French J, Gelinas J, Grover P, Picard R (2022) Building a culture of responsible neurotech: neuroethics as socio-technical challenges. Neuron. Jul 6;110(13):2057-62. PDF ​ Pouliopoulos AN, Murillo MF, Noel RL, Batts AJ, Ji R, Kwon N, Yu H, Tong CK, Gelinas JN, Araghy DK, Hussaini SA, Konofagou EE* (2022) Non-invasive optogenetics with ultrasound-mediated gene delivery and red-light excitation. Brain stimulation. Jul 1;15(4):927-41. PDF ​ Silverå Ejneby M, Jakešová M, Ferrero JJ, Migliaccio L, Sahalianov I, Zhao Z, Berggren M, Khodagholy D, Đerek V*, Gelinas JN*, Głowacki ED* (2022) Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor. Nature Biomedical Engineering. Jun;6(6):741-53. PDF